|
S-nitrosylation (SNO) is a type of reversible post-translational modification (PTM) of protein that plays a key role in regulating many cellular plasticity and dynamics. In the SNO process, a thiol group is covalently attached to the cysteine residues by recycling nitric oxide. Different studies suggest SNO on cysteine are critical, especially in redox pathways, cardiovascular, immune, neuronal, and plant systems and controls the various pathophysiological events, such cancers and diabetes. The detail mechanisms of SNO still remain to be elucidated, due to the low abundance and labile nature of SNO. Therefore, identification of SNO sites is essential for understanding in both the pathological and physiological mechanisms as well as basic research of drug development.
|