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Microbial phosphorylation site predictor, is an integrative web resource for prediction microbial protein. This server is freely available to any user, but without any warranty.

About microbial phosphorylation protein


Protein phosphorylation is one type of post-translational modification (PTM) that plays an important role in regulating signal transduction pathway. Since 1932, eukaryotes have extensively been studied and most of the identified phosphorylation acceptor residues were serine (S), and threonine (T) [1].

Different studies suggest that phosphorylation on S and T residues is critical for functional regulation and signaling transduction [2].

Recently, some leading studies have expanded an understanding of molecular mechanisms and functional roles in microbial phosphorylation [3]. Although the experimental determination of microbial phosphorylation proteins with specific modified sites is increasing in the present era, the mechanism of phosphorylation specificity is still largely unknown until now.

Therefore, identification of microbial phosphorylation sites is necessary for further elucidating the mechanism of phosphorylation.

References


1. Cohen P. The origins of protein phosphorylation. Nature cell biology. May 2002;4(5):E127-130.

2. Ptacek J, Devgan G, Michaud G, et al. Global analysis of protein phosphorylation in yeast. Nature. Dec 1 2005;438(7068):679-684.

3. Pan Z, Wang B, Zhang Y, et al. dbPSP: a curated database for protein phosphorylation sites in prokaryotes. Database : the journal of biological databases and curation. 2015;2015:bav031.










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